ODCs

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2 OMIM references -
2 associated genes
10 signs/symptoms

PROTEIN INTERACTIONS: 1

1 OMIM reference -
1 associated gene
No signs/symptoms info

Isolated 3-methylcrotonyl-CoA carboxylase deficiency

Autosomal dominant spastic paraplegia type 13

MCCC1	(UniProt - OMIM)		HSPD1	(UniProt - OMIM)
MCCC2	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	MCCC2	(0.49)	HSPD1

Citations in the biomedical literature:

Isolated 3-methylcrotonyl-CoA carboxylase deficiency		Autosomal dominant spastic paraplegia type 13
	Synonym(s): - 3-methylcrotonylglycinuria - MCC deficiency - MCCD		Synonym(s): - SPG13

	Classification (Orphanet): - Inborn errors of metabolism - Rare genetic disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease

	Classification (ICD10): - Endocrine, nutritional and metabolic diseases -		Classification (ICD10): - Diseases of the nervous system -

	Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: - Average age of death: - Type of inheritance: autosomal dominant

	External references: 2 OMIM references - 1 MeSH reference: C535308		External references: 1 OMIM reference - 1 MeSH reference: C537485

Isolated 3-methylcrotonyl-CoA carboxylase deficiency
	Very frequent - Hypoglycemia - Hypotonia - Metabolic anomalies - Organic acid metabolism anomalies Frequent - Failure to thrive / difficulties for feeding in infancy / growth delay - Hyperammonemia - Movement disorder Occasional - Cerebral vascular anomalies - Hypertonia / spasticity / rigidity / stiffness - Respiratory distress / dyspnea / respiratory failure / lung volume reduction
Autosomal dominant spastic paraplegia type 13
(no data available)